In this study, the oxidation of vanillic acid (VA) into protocatechuic acid (PCA) was investigated using montmorillonite KSF as inexpensive and environmentally benign solid acid, with peroxide hydrogen to afford excellent yields (more than 75%) endowed with high selectivity. To our knowledge, the aforementioned method was used for the first time in green, clean synthesis. The influence of the several operating parameters were performed using an experimental design Box–Behnken methodology. The progress of the concentrations of VA and its oxidation product PCA was accomplished using ultra-high-performance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (RP-UHPLC-DAD-QTOF-MS) and mass spectrometry. Accordingly, PCA would be advantageous when used in food as well as cosmetic and pharmaceutical industries. Finally, a mechanistic pathway for the VA oxidation was proposed.

中文翻译：

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蒙脱石粘土氧化香草酸的动力学及机理。

在这项研究中，使用蒙脱土KSF作为廉价且对环境无害的固体酸和过氧化物氢，将香草酸（VA）氧化为原儿茶酸（PCA），可提供出色的收率（超过75％），并具有高选择性。据我们所知，上述方法首次用于绿色，纯净的合成中。使用实验设计Box–Behnken方法进行了几个操作参数的影响。使用超高效液相色谱，四极杆飞行时间质谱（RP-UHPLC-DAD-QTOF-MS）和质谱，可以完成VA及其氧化产物PCA浓度的提高过程。因此，当用于食品以及化妆品和制药工业中时，PCA将是有利的。最后，