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New 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols with antituberculosis activity
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2019-10-01 , DOI: 10.1007/s11172-019-2646-5 A. V. Omel’kov , V. E. Fedorov , A. A. Stepanov
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2019-10-01 , DOI: 10.1007/s11172-019-2646-5 A. V. Omel’kov , V. E. Fedorov , A. A. Stepanov
New 4-dimethylamino-2-(naphthalen-1-yl)-1-phenyl-1-(quinolin-3-yl)butan-2-ols with antituberculosis activity were synthesized. (1R*,2S*)-1-(6-Bromo-2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ol hydrocitrate exhibiting high antituberculosis activity is in the final stage of clinical trials and is prepared for use in clinical practice.
中文翻译：
具有抗结核活性的新型 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols
合成了具有抗结核活性的新型4-二甲氨基-2-(naphthalen-1-yl)-1-phenyl-1-(quinolin-3-yl)butan-2-ols。(1R*,2S*)-1-(6-Bromo-2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ol hydrocitrate 具有高抗结核活性处于临床试验的最后阶段，准备用于临床实践。
更新日期：2019-10-01
中文翻译：
具有抗结核活性的新型 1-(2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ols
合成了具有抗结核活性的新型4-二甲氨基-2-(naphthalen-1-yl)-1-phenyl-1-(quinolin-3-yl)butan-2-ols。(1R*,2S*)-1-(6-Bromo-2-chloroquinolin-3-yl)-4-dimethylamino-2-(naphthalen-1-yl)-1-phenylbutan-2-ol hydrocitrate 具有高抗结核活性处于临床试验的最后阶段，准备用于临床实践。
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