Zwitterionic Gemini surfactants have the Gemini molecular structure in which there are both multiple lipophilic groups and multiple hydrophilic groups. However, their hydrophilic groups have different charges. Due to the special molecular structure, this kind of surfactants possesses excellent properties, including high surface activities, isoelectric point (IP), low critical micelle concentration (CMC), less toxicity, low irritating, biodegradability, bioactive, interface modification, and so on. In this review, synthetic strategies of three kinds of zwitterionic Gemini surfactants, i.e., anioniccationic, cationic-nonionic and anionic-nonionic Gemini surfactants, are discussed, and their potential applications in life sciences, chemical industry and enhanced oil recovery (EOR) are illustrated. Their future development is also prospected.

两性离子双子表面活性剂具有双子分子结构，其中同时存在多个亲脂基团和多个亲水基团。但是，它们的亲水基团具有不同的电荷。由于特殊的分子结构，这种表面活性剂具有优异的性能，包括高表面活性，等电点（IP），低临界胶束浓度（CMC），毒性小，刺激性低，生物降解性，生物活性，界面改性等。 。在这篇综述中，讨论了三种两性离子双子表面活性剂的合成策略，即阴离子阳离子，阳离子-非离子和阴离子-非离子双子表面活性剂，并阐述了它们在生命科学，化学工业和提高油采收率（EOR）中的潜在应用。 。他们的未来发展也有希望。