An aligned composite film was fabricated via the deposition of carboxylic graphene oxide (C-GO) and polypyrrole (PPy) nanoparticles on aligned poly(L-lactic acid) (PLLA) fiber-films (named as C-GO/PPy/PLLA), which has the core (PLLA)-sheath (C-GO/PPy) structure, and the composition of C-GO (∼4.8 wt.% of PPy sheath) significantly enhanced the tensile strength and the conductivity of the PPy/PLLA film. Especially, after 4 weeks of immersion in the PBS solution, the conductivity and the tensile strength of C-GO/PPy/PLLA films still remained ∼6.10 S/cm and 28.9 MPa, respectively, which could meet the need of the sustained electrical stimulation (ES) therapy for nerve repair. Moreover, the neurite length and the neurite alignment were significantly increased through exerting ES on C-GO/PPy/PLLA films due to their sustained conductivity in the fluid of cell culture. These results indicated that C-GO/PPy/PLLA with sustained conductivity and mechanical property possessed great potential of nerve repair by exerting lasting-ES.

通过在对齐的聚（L-乳酸）（PLLA）纤维膜上沉积碳氧化石墨烯（C-GO）和聚吡咯（PPy）纳米颗粒（称为C-GO / PPy / PLLA）制备对齐的复合膜具有芯（PLLA）-护套（C-GO / PPy）结构，并且C-GO的成分（约占4.8 wt。％的PPy护套）显着提高了PPy / PLLA膜的拉伸强度和导电性。尤其是在PBS溶液中浸泡4周后，C-GO / PPy / PLLA薄膜的电导率和拉伸强度仍分别保持在〜6.10 S / cm和28.9 MPa，可以满足持续电刺激的需要。 （ES）神经修复疗法。而且，通过在C-GO / PPy / PLLA膜上施加ES，由于其在细胞培养液中的持续电导率，神经突长度和神经突排列显着增加。这些结果表明，具有持续电导率和机械性能的C-GO / PPy / PLLA通过施加持久的ES具有巨大的神经修复潜力。