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Particle size control of monodispersed spherical nanoparticles with MCM-48-type mesostructure via novel rapid synthesis procedure
Journal of Nanoparticle Research ( IF 2.5 ) Pub Date : 2019-11-25 , DOI: 10.1007/s11051-019-4699-7
Shewaye Yismaw , Richard Kohns , Denise Schneider , David Poppitz , Stefan G. Ebbinghaus , Roger Gläser , Ulrich Tallarek , Dirk Enke

Monodispersed spherical silica nanoparticles with a cubic mesostructure were synthesized in a fast and innovative way using triethanolamine (TEA) and the triblock copolymer Pluronic® F127 as particle growth inhibitors to control the particle size in a range from 420 to 62 nm. In this study, we described a synthesis of mesoporous silica nanoparticles (MSNs) with MCM-48 structure at room temperature with adequate control of particle monodispersity, shape, and size using TEA. Based on particle characterization, TEA can efficiently act as catalyst and at the same time as particle growth controlling additive. A mixture of TEA and Pluronic® F127 additives was used to obtain very small MSNs (62 nm), whereby the quality of MCM-48 silica is associated with the composition of the additives used and thus also with the final particle size. A finely dispersed and high-quality MCM-48 material with ~ 100% yield, excellent textural properties, and a particle size of 295 nm was synthesized within only 35 min using excess TEA as particle size controlling and dispersion agent together with ammonia as additional catalyst. Solvent extraction combined with ion exchange removed the surfactant efficiently. All prepared MSNs showed good textural properties, tunable particle sizes with narrow size distributions, and good dispersity in water, which make them highly promising as carriers for biomolecules in biomedical applications.

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中文翻译:

通过新型快速合成程序控制具有MCM-48型介观结构的单分散球形纳米颗粒的粒径

使用三乙醇胺(TEA)和三嵌段共聚物F127作为颗粒生长抑制剂,以快速创新的方式合成了具有立方介孔结构的单分散球形二氧化硅纳米颗粒。在这项研究中,我们描述了在室温下使用TEA合成具有MCM-48结构的介孔二氧化硅纳米粒子(MSN),并充分控制了粒子的单分散性,形状和尺寸。基于颗粒表征,TEA可以有效地充当催化剂,同时还可以充当颗粒生长控制添加剂。TEA和F127添加剂的混合物用于获得非常小的MSN(62 nm),因此MCM-48二氧化硅的质量与所用添加剂的组成有关,因此也与最终粒径有关。使用过量的TEA作为粒度控制剂和分散剂以及氨水作为辅助催化剂,仅需35分钟即可合成出一种精细分散的高质量MCM-48材料,产率约为100%,具有优异的质构特性,并且粒径为295 nm。 。溶剂萃取结合离子交换可有效去除表面活性剂。所有制备的MSN均显示出良好的质地特性,可调的粒径,窄的粒径分布以及在水中的良好分散性,这使其在生物医学应用中作为生物分子的载体具有很高的前景。溶剂萃取结合离子交换可有效去除表面活性剂。所有制备的MSN均显示出良好的质地特性,可调的粒径,窄的粒径分布以及在水中的良好分散性,这使其在生物医学应用中作为生物分子的载体具有很高的前景。溶剂萃取结合离子交换可有效去除表面活性剂。所有制备的MSN均显示出良好的质地特性,可调的粒径,窄的粒径分布以及在水中的良好分散性,这使其在生物医学应用中作为生物分子的载体具有很高的前景。

更新日期:2019-11-25
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