Nowadays, due to a growing number of tissue injuries, in particular, skin wounds, induction and promotion of tissue healing responses can be considered as a crucial step towards a complete regeneration. Recently, biomaterial design has been oriented towards promoting a powerful, effective, and successful healing. Biomaterials with wound management abilities have been developed for different applications such as providing a native microenvironment and supportive matrices that induce the growth of tissue, creating physical obstacles against microbial contamination, and to be used as delivery systems for therapeutic reagents. Until now, numerous strategies aiming to accelerate the wound healing process have been utilized and studied with their own pros and cons. In this review, tissue remodeling phenomena, wound healing mechanisms, and their related factors will be discussed. In addition, different methods for induction and acceleration of healing via cell therapy, bioactive therapeutic delivery, and/or biomaterial-based approaches will be reviewed.

如今，由于越来越多的组织损伤，特别是皮肤伤口，诱导和促进组织愈合反应可被视为迈向完全再生的关键步骤。最近，生物材料设计的方向是促进强大，有效和成功的愈合。具有伤口处理能力的生物材料已被开发用于不同的应用，例如提供天然的微环境和支持性基质，这些组织可诱导组织生长，对微生物污染产生物理障碍，并可用作治疗试剂的递送系统。到目前为止，已经利用了许多旨在加速伤口愈合过程的策略，并且各有其优缺点。在这篇评论中，组织重塑现象，伤口愈合机制，以及它们的相关因素将被讨论。另外，将综述通过细胞疗法，生物活性治疗剂和/或基于生物材料的方法诱导和加速愈合的不同方法。