The present study provides credence to the formation of polyvinyl alcohol (PVA)–Azadirachta indica (neem) nanofibrous mat (PNNM) under optimum processing conditions of electrospinning technique from a mixer of PVA and neem extract to utilize the inherent medicinal properties of this herb for biomedical application. The bonding behavior, orientation of fibers, thermal behavior, and moisture management properties were evaluated by Fourier transforms infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermo gravimetric analysis (TGA) and moisture management tester (MMT) reports respectively. The antibacterial activity of the developed sample at the maximum mixing ratio of neem extract (80%) was tested against Gram-positive (S. aureus) bacteria using agar disc diffusion method. The results reveal that the prepared nanofibrous mat exhibited better thermal and moisture management properties in comparison with PVA nanofiber alone. The formation of smooth fibers was confirmed by SEM images having average diameter of 185 nm under 5k, 10k and 15k magnifications. The characteristic peaks of PVA and neem constituents in FTIR spectra of the developed mat confirmed the presence of both components. Bacterial resistance was reached up to 20 mm due to the antibacterial constituents of neem extract. Thus the developed mat could be used as a biocompatible and bio based in biomedical applications.

中文翻译：

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聚乙烯醇（PVA）–印度生物印A（Neem）纳米纤维垫：形成和表征

本研究提供信用到聚乙烯醇的形成（PVA） -印楝从PVA和印度楝树提取物的混合器静电纺丝技术，利用这种草药的固有药性为（印楝）纳米纤维垫（PNNM）下最佳的加工条件生物医学应用。分别通过傅立叶变换红外光谱（FTIR），扫描电子显微镜（SEM），热重分析（TGA）和水分管理测试仪（MMT）报告评估了粘合行为，纤维取向，热行为和水分管理性能。测试了所开发样品在印em提取物最大混合比（80％）下对革兰氏阳性（金黄色葡萄球菌）的抗菌活性。）细菌采用琼脂圆盘扩散法。结果表明，与单独的PVA纳米纤维相比，制备的纳米纤维垫表现出更好的热和湿气管理性能。通过在5k，10k和15k放大率下具有185nm的平均直径的SEM图像确认了平滑纤维的形成。显影垫的FTIR光谱中PVA和印em成分的特征峰证实了这两种成分的存在。由于印em提取物的抗菌成分，细菌抵抗力达到了20 mm。因此，开发的垫可以用作生物医学应用中的生物相容性和生物基材料。