A p-type transition metal dichalcogenide (WS₂) was synthesized and hybridized with graphene oxide via a simple hydrothermal method. The as-prepared material was used to modify a glassy carbon electrode for the fabrication of a simple, stable, and repeatable methylene blue-labeled “signal-off” aptasensor used for the sensitive determination of very low amounts of sodium diclofenac (DCF). The synthetic material, modification process, and role of WS₂ in the current response enhancement were studied by X-ray diffraction, energydispersive X-ray spectroscopy, field emission scanning electron microscopy, high resolution transmission electron microscopy, Hall effect, cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. Subsequently, a wide linear range of DCF concentration (0.5–300 nmol/L), very low limit of detection (0.23 nmol/L), and good selectivity were obtained using the differential pulse voltammetry method with the assembled aptasensor. Finally, the fabricated aptasensor was successfully developed for physiological real samples with significant recoveries.

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甲p型过渡金属二硫属化物（WS ₂）合成，并通过一个简单的水热法用氧化石墨烯杂交。所制备的材料用于修饰玻碳电极，以制造简单，稳定且可重复的亚甲基蓝标记的“信号”适体传感器，用于灵敏测定非常少量的双氯芬酸钠（DCF）。WS ₂的合成材料，修改过程和作用通过X射线衍射，能量色散X射线光谱，场发射扫描电子显微镜，高分辨率透射电子显微镜，霍尔效应，循环伏安法，差动脉冲伏安法和电化学阻抗光谱学研究了电流响应增强中的电流。随后，使用差分脉冲伏安法和组装的适体传感器获得了DCF浓度的宽线性范围（0.5–300 nmol / L），极低的检测下限（0.23 nmol / L）和良好的选择性。最终，成功开发出了适用于具有显着回收率的生理真实样品的适体传感器。

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