OBJECTIVE Blood oxygenation level dependent (BOLD) MRI technique is used to evaluate changes in intra-renal oxygenation in chronic kidney disease (CKD). The purpose of this study was to evaluate if the novel twelve layer concentric objects (TLCO) method has advantages over the manually defined regions of interest (ROI) analysis. METHODS AND MATERIALS Existing renal BOLD MRI data acquired before and after furosemide on a 3 T scanner from 41 CKD patients and 13 age matched healthy controls were analyzed using TLCO method and compared with previously reported ROI analysis. RESULTS Regional R2* measurements were strongly correlated between the two methods, while ΔR2* was moderately correlated. Medullary R2* by ROI analysis showed higher values compared to R2*_Inner by TLCO, probably due to the contributions from the cortex to R2*_Inner. R2*_Slope and Δ(R2*_Slope), unique parameters based on the TLCO method provided the most significant differences between stage 3a CKD patients and controls and were correlated with eGFR. DISCUSSION There was a high degree of agreement between the two methods in terms of regional R2* measurements and both methods did not show differences between moderate CKD patients and controls. However, R2*_Slope and Δ(R2*_Slope) showed the largest sensitivity in distinguishing CKD from controls.

中文翻译：

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慢性肾脏病患者的肾脏 BOLD MRI：半自动十二层同心物体 (TLCO) 和手动 ROI 方法的比较。

目的 血氧水平依赖 (BOLD) MRI 技术用于评估慢性肾脏病 (CKD) 中肾内氧合的变化。本研究的目的是评估新的十二层同心物体 (TLCO) 方法是否比手动定义的感兴趣区域 (ROI) 分析具有优势。方法和材料 使用 TLCO 方法对 41 名 CKD 患者和 13 名年龄匹配的健康对照者在呋塞米之前和之后在 3 T 扫描仪上采集的现有肾脏 BOLD MRI 数据进行分析，并与之前报道的 ROI 分析进行比较。结果 区域 R2* 测量值在两种方法之间具有很强的相关性，而 ΔR2* 是中度相关的。与 TLCO 的 R2*_Inner 相比，ROI 分析的髓质 R2* 显示更高的值，这可能是由于皮层对 R2*_Inner 的贡献。R2*_Slope 和 Δ(R2*_Slope)，基于 TLCO 方法的独特参数提供了 3a 期 CKD 患者和对照组之间最显着的差异，并且与 eGFR 相关。讨论 两种方法在区域 R2* 测量方面高度一致，两种方法均未显示中度 CKD 患者和对照组之间的差异。然而，R2*_Slope 和 Δ(R2*_Slope) 在区分 CKD 和对照方面表现出最大的敏感性。