Abstract

Natural compounds of botanical origin are increasingly being investigated for the development of novel biocides. Intensive use of synthetic biocides and the confined array of chemical classes in use has led to the buildup of unwanted residues and to parasites’ adaptive responses and resistance. Meanwhile, the geographic and host ranges of arthropod vectors and vector-borne diseases are broadening. In an effort to develop “friendly” biocidal compounds for the environment and human health, plant secondary metabolites originating in a number of botanical families could be engaged. This mini-review compiles the recently available knowledge on plant secondary metabolites exhibiting biocidal properties and provides a brief overview on their activity against arthropods with a focus on toxic and repellent properties. The selected examples show that it is valuable to consider plants as a promising source for new products development to support the fight against arthropods related to human health. Finally, we outline the biocides regulatory framework in the European Union (EU) and pinpoint some issues of concern regarding the development of low risk biocides.

Graphic abstract

Plant secondary metabolites acting against arthropods of medical importance

中文翻译：

---

植物抗代谢节肢动物的次生代谢产物

抽象的

越来越多地研究植物来源的天然化合物以开发新型杀生物剂。大量使用合成杀生物剂和使用受限的化学类别，导致了不想要的残留物的积累，并导致了寄生虫的适应性反应和抗药性。同时，节肢动物媒介和媒介传播疾病的地理和宿主范围正在扩大。为了开发对环境和人类健康有益的“友好”杀菌化合物，可以利用源自多个植物家庭的植物次生代谢产物。这份小型综述汇集了有关具有杀生物特性的植物次生代谢产物的最新知识，并简要概述了它们对节肢动物的活性，重点是毒性和驱避性。选定的例子表明，将植物视为支持与人类健康有关的节肢动物斗争的新产品开发的有希望的来源是很有价值的。最后，我们概述了欧盟（EU）中的杀菌剂监管框架，并指出了有关开发低风险杀菌剂的一些令人关注的问题。

图形摘要

植物次生代谢物对节肢动物有重要作用