BACKGROUND The clinical value of the controlling nutritional status (CONUT) score in hepatocellular carcinoma (HCC) has increased. The aim of this meta-analysis was to systematically review the association between the CONUT score and outcomes in patients undergoing hepatectomy for HCC. METHODS Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar were systematically searched. Random effects meta-analyses were conducted to examine the prognostic value of the CONUT score in HCC patients. RESULTS A total of five studies including 4679 patients were found to be eligible and analyzed in the meta-analysis. The CONUT score was significantly associated with overall survival (HR 1.78, 95%CI = 1.20-2.64, P = 0.004, I2 = 79%), recurrence-free survival (HR 1.34, 95%CI = 1.17-1.53, P < 0.001, I2 = 16%) and postoperative major complications (OR 1.85, 95%CI: 1.19-2.87, P = 0.006, I2 = 72%) in HCC patients. Moreover, the CONUT score was associated with the Child-Pugh classification, liver cirrhosis, ICGR15, and tumor differentiation. However, it was not associated with tumor size, tumor number, and microvascular invasion. CONCLUSIONS The CONUT score is an independent prognostic indicator of the prognosis and is associated with postoperative major complications and hepatic functional reserve in HCC patients.

中文翻译：

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控制性营养状况（CONUT）评分在肝癌肝切除术患者中的预后意义：系统评价和荟萃分析。

背景技术在肝细胞癌（HCC）中控制营养状况（CONUT）评分的临床价值已经提高。这项荟萃分析的目的是系统地审查接受肝癌肝切除术的患者的CONUT评分与预后之间的关联。方法系统地搜索Embase，Medline Ovid，Web of Science，Cochrane CENTRAL和Google Scholar。进行了随机效应荟萃分析，以检查CONUT评分在HCC患者中的预后价值。结果在荟萃分析中发现总共有5项研究（包括4679例患者）符合条件并进行了分析。CONUT评分与总体生存率显着相关（HR 1.78，95％CI = 1.20-2.64，P = 0.004，I2 = 79％），无复发生存率（HR 1.34，95％CI = 1.17-1.53​​，P <0.001 ，I2 = 16％）和HCC患者的术后重大并发症（OR 1.85，95％CI：1.19-2.87，P = 0.006，I2 = 72％）。此外，CONUT评分与Child-Pugh分类，肝硬化，ICGR15和肿瘤分化有关。但是，它与肿瘤大小，肿瘤数目和微血管浸润无关。结论CONUT评分是预后的独立预后指标，与HCC患者的术后主要并发症和肝功能储​​备有关。