Type 3 Inositol 1,4,5-trisphosphate (IP3) receptors (IP3R3s) have been identified as anti-oncogenic channels by propelling pro-apoptotic Ca2+ signals to mitochondria. Yet, recent studies (Rezuchova et al, Cell Death Dis, 2019; Ueasilamongkol et al, Hepathology, 2019; Guerra et al, Gut, 2019) revealed that IP3R3 upregulation drives oncogenesis via ER-mitochondrial Ca2+ crosstalk, adding complexity to IP3R3's role in cancer.

中文翻译：

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驱动肿瘤发生的3型IP3受体。

通过将促凋亡的Ca2 +信号传递至线粒体，已将3型肌醇1,4,5-三磷酸（IP3）受体（IP3R3s）鉴定为抗致癌通道。然而，最近的研究（Rezuchova等人，Cell Death Dis，2019; Ueasilamongkol等人，Hepathology，2019; Guerra等人，Gut，2019）显示IP3R3上调通过ER-线粒体Ca2 +串扰驱动肿瘤发生，增加了IP3R3在中的作用癌症。