Hypoxia and acidity in the tumor microenvironment promote resistance to immunotherapy. Hypoxia upregulates multiple immunoinhibitory pathways, including VISTA, and acidity enables VISTA to interact with PSGL-1 to inhibit immune activation selectively in the acidic tumor microenvironment.

中文翻译：

---

酸度改变免疫学：一种新的VISTA途径。

肿瘤微环境中的缺氧和酸性会增强对免疫疗法的抵抗力。缺氧会上调多种免疫抑制途径，包括VISTA，而酸性可使VISTA与PSGL-1相互作用，从而在酸性肿瘤微环境中选择性抑制免疫激活。