IL-33 is shown to play a cell-intrinsic role in maintenance of the functional identity of regulatory T cells in the tumor microenvironment. Genetic inhibition of IL-33 potentiates the therapeutic effect of checkpoint inhibitor immunotherapy in a melanoma mouse tumor model.

中文翻译：

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脆弱性在癌症中可能是一件好事。

IL-33 显示在维持肿瘤微环境中调节性 T 细胞的功能特性方面发挥细胞内在作用。IL-33 的遗传抑制增强了检查点抑制剂免疫疗法在黑色素瘤小鼠肿瘤模型中的治疗效果。