Abstract Microvasculature plays a decisive role on the normal operation of the human body. Previous studies have shown that the causes of microvascular hemolytic anemia and other diseases are closely related to the interaction between micro-thrombi and RBCs. The movement and deformation of Red Blood Cells (RBCs) in microvasculature with hemicyclic micro-thrombi of different sizes on the wall are simulated based on the Moving Particle Semi-implicit method (MPS) and the spring network model of RBCs membrane. Simulation of a single RBC passing the straight blood vessel indicates the strong squeeze of the RBC caused by the thrombus, which leads to a 38.5% increasing of the RBC velocity and a greater deformation, and such squeeze effect is positively related with the size of the thrombus. When two RBCs pass through the straight blood vessel with two thrombi on the both sidewalls, the deformation of the RBCs first increases and then decreases. Results show that when the axial position between the two thrombi is 10 × d0 different, the deformation of RBCs reaches the maximum of 3.10 (upper) and 2.79 (lower), respectively. When two side-by-side RBCs pass through a bifurcated blood vessel with a sidewall thrombus, the velocity and deformation of RBCs are greatly affected by the thrombus. When the thrombus radius changes from 0 × d0 to 20 × d0, the peak velocities of the two cells increase by 51.6% (upper) and 67.9% (lower), respectively.

中文翻译：

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使用移动粒子半隐式方法研究血栓对微血管系统中红细胞流动的影响

摘要 微血管对人体的正常运作起着决定性的作用。以往的研究表明，微血管溶血性贫血等疾病的病因与微血栓与红细胞的相互作用密切相关。基于移动粒子半隐式方法（MPS）和RBCs膜的弹簧网络模型，模拟了红细胞（RBCs）在壁上具有不同大小的半环状微血栓的微血管中的运动和变形。单个红细胞通过直血管的模拟表明，血栓对红细胞产生强烈挤压，导致红细胞速度增加38.5%，变形更大，这种挤压效应与血管大小呈正相关。血栓。当两个红细胞通过两侧壁有两个血栓的直血管时，红细胞的变形先增大后减小。结果表明，当两个血栓之间的轴向位置相差 10 × d0 时，RBC 的变形分别达到最大值 3.10（上）和 2.79（下）。当两个并排的红细胞通过带有侧壁血栓的分叉血管时，红细胞的速度和变形受血栓的影响很大。当血栓半径从 0 × d0 变为 20 × d0 时，两个细胞的峰值速度分别增加了 51.6%（上）和 67.9%（下）。RBC 的变形分别达到 3.10（上）和 2.79（下）的最大值。当两个并排的红细胞通过具有侧壁血栓的分叉血管时，红细胞的速度和变形受血栓的影响很大。当血栓半径从 0 × d0 变为 20 × d0 时，两个细胞的峰值速度分别增加了 51.6%（上）和 67.9%（下）。RBC 的变形分别达到 3.10（上）和 2.79（下）的最大值。当两个并排的红细胞通过带有侧壁血栓的分叉血管时，红细胞的速度和变形受血栓的影响很大。当血栓半径从 0 × d0 变为 20 × d0 时，两个细胞的峰值速度分别增加了 51.6%（上）和 67.9%（下）。