More than 60% newborns experience hyperbilirubinemia and jaundice within the initial week after birth due to the accumulation of total bilirubin in blood. Left untreated high levels of bilirubin may result in brain impairment. Simple, fast, accurate, low-cost and timely point-of-care (POC) analysis of total bilirubin is an unmet need especially in resource-limited areas. This work introduces a novel sensing device, named a "tape-paper sensor", capable of separating plasma from whole blood and measuring total bilirubin by a colorimetric diazotization method. The tape-paper sensing method overcomes non-homogeneous color distribution caused by the "coffee stain" effect, which improves the accuracy of colorimetric evaluation on paper-based analytical devices. The level of hemolysis in the plasma extracted by the device is evaluated, confirming no interference in the detection of total bilirubin. The accuracy of the tape-paper sensing approach for neonatal blood sample measurement is verified by comparison with the hospital pathology laboratory method. The small volume of samples and reagents, minimal equipment (an office scanner), fast detection (<10 min) and low fabrication cost (∼A$ 0.6) reveal the suitability of the device for POC use and in resource-limited settings. The tape-paper sensor is a low-cost, fast, and user-friendly device for measurement of blood total bilirubin levels in neonatal jaundice diagnostics.

中文翻译：

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基于三维微流控胶带纸的传感设备，用于黄疸新生儿的血液总胆红素测量。

由于血液中总胆红素的积累，超过60％的新生儿在出生后的最初一周内会出现高胆红素血症和黄疸。如果不及时治疗，高水平的胆红素可能会导致脑部损害。对于总胆红素的简单，快速，准确，低成本和及时的即时护理（POC）分析是未满足的需求，尤其是在资源有限的地区。这项工作介绍了一种新颖的传感设备，称为“纸带传感器”，它能够从全血中分离血浆并通过比色重氮化法测量总胆红素。带纸感测方法克服了由“咖啡渍”效应引起的不均匀的颜色分布，从而提高了基于纸的分析设​​备的比色评估的准确性。评估设备提取的血浆中的溶血水平，确认对总胆红素的检测无干扰。通过与医院病理实验室方法的比较，验证了纸带传感方法测量新生儿血液样本的准确性。少量的样品和试剂，最少的设备（办公室扫描仪），快速的检测（<10分钟）和较低的制造成本（约0.6澳元）表明该设备适用于POC和资源受限的环境。带纸传感器是一种低成本，快速且用户友好的设备，可用于新生儿黄疸诊断中血液总胆红素水平的测量。少量的样品和试剂，最少的设备（办公室扫描仪），快速的检测（<10分钟）和较低的制造成本（约0.6澳元）表明该设备适用于POC和资源受限的环境。带纸传感器是一种低成本，快速且用户友好的设备，可用于新生儿黄疸诊断中血液总胆红素水平的测量。少量的样品和试剂，最少的设备（办公室扫描仪），快速的检测（<10分钟）和较低的制造成本（约0.6澳元）表明该设备适用于POC和资源受限的环境。带纸传感器是一种低成本，快速且用户友好的设备，可用于新生儿黄疸诊断中血液总胆红素水平的测量。