当前位置: X-MOL 学术J. Nat. Prod. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cytotoxic 20,22-Dihydrodigitoxigenin Glycosides and Other Constituents of Vallaris glabra Stems.
Journal of Natural Products ( IF 5.1 ) Pub Date : 2019-12-10 , DOI: 10.1021/acs.jnatprod.9b00803
Sudarat Kruakaew 1 , Chonticha Seeka 1 , Jantana Yahuafai 2 , Pongpun Siripong 2 , Somyote Sutthivaiyakit 1
Affiliation  

Ten cardiac glycosides (1-10) including six 20,22-dihydrodigitoxigenin and four gitoxigenin glycosides were isolated from the stems of Vallaris glabra together with six known triterpenoid cinnamates. Spectroscopic data of these previously undescribed compounds are reported. All isolates were evaluated for their growth inhibitory activities against three cancer cell lines, and compound 2 was the most active against KB cells with an IC50 value of 0.03 ± 0.001 μM. Also, compounds 1, 3, 5, and 6 and the triterpenoid cinnamates 11-13 showed inhibitory activity (IC50 < 10 μM) for one or more of the cell lines used.

中文翻译:

细胞毒性的20,22-Dihydrodigitoxigenin糖苷和其他Vallaris glabra茎成分。

从Vallaris glabra的茎中分离出十种强心苷(1-10),其中包括六种20,22-dihydrodigitoxigenin和四种gitoxigenin苷,以及六种已知的三萜类肉桂酸酯。报道了这些先前未描述的化合物的光谱数据。评估了所有分离株对三种癌细胞的生长抑制活性,化合物2对KB细胞的活性最高,IC50值为0.03±0.001μM。同样,化合物1、3、5和6以及三萜类肉桂酸酯11-13对一种或多种所用细胞系显示抑制活性(IC50 <10μM)。
更新日期:2019-12-11
down
wechat
bug