Three new p-terphenyl derivatives, nocarterphenyls A-C (1-3), along with three known analogues (4-6) were isolated from the marine-derived actinobacterial strain Nocardiopsis sp. OUCMDZ-4936. Their structures were elucidated on the basis of spectroscopic analysis and a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possess a benzothiazole and benzothiazine moiety, respectively, which are rare in the skeleton of p-terphenyls. Nocarterphenyl A (1) showed potent cytotoxic activity against the HL60 and HCC1954 cancer cell lines with the IC50 values of 0.38 and 0.10 μM among 26 human cancer cell lines.

中文翻译：

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海洋衍生的拟南芥属物种的细胞毒性对三联苯。

从海洋来源的放线菌菌株Nocardiopsis sp。中分离出了三种新的对-三联苯衍生物，邻三联苯AC（1-3）以及三种已知的类似物（4-6）。OUCMDZ-4936。在光谱分析和单晶X射线衍射实验的基础上阐明了它们的结构。化合物1和2分别具有苯并噻唑和苯并噻嗪部分，这在对-三联苯的骨架中是罕见的。Nocarterphenyl A（1）在26种人类癌细胞系中显示出对HL60和HCC1954癌细胞系的有效细胞毒活性，IC50值为0.38和0.10μM。