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Performance in delayed non-matching to sample task predicts the diagnosis of obsessive-compulsive disorder.
Translational Psychiatry ( IF 6.8 ) Pub Date : 2019-12-10 , DOI: 10.1038/s41398-019-0667-3
Redwan Maatoug 1 , Benoît Le Goff 2 , Jean-Yves Rotge 1 , Nemat Jaafari 3 , Olivier Guillin 2 , Bruno Millet 1
Affiliation  

Electrical stimulation studies have recently evidenced the involvement of orbitofrontal cortex (OFC) in obsessive-compulsive disorder (OCD). In addition, lateral OFC is activated in healthy subjects during delayed non-matching-to-sample task (DNMS). In the present study, we hypothesized that OCD results from a specific defect of lateral OFC processing that can be evidenced via a DNMS task. To this end, we compared the DNMS performances of 20 OCD patients vs 20 demographically matched healthy controls. As predicted, our results showed that OCD patients performed worse than healthy controls at DNMS task. To test for the specificity of this behavioral impairment, we furthermore compared OCD patients and healthy subjects on a different task not involving directly the lateral OFC: the delayed match-to-sample task (DMS). As expected, OCD patients are more impaired for both the DNMS and the DMS task, compared with healthy subjects. Moreover, OCD patients tend statistically to perform worse for the DNMS task than for DMS task. Our results suggest the DNMS task specifically target the malfunctioning areas in OCD, such as the lateral OFC. In light of these results, lateral OFC should therefore be the focus of future therapeutic interventions.

中文翻译:

延迟不匹配样本任务的表现预示着强迫症的诊断。

电刺激研究最近证明强迫症(OCD)涉及眶额叶皮层(OFC)。另外,在延迟的不匹配样本任务(DNMS)期间,健康受试者的侧面OFC被激活。在本研究中,我们假设OCD是由OFC横向加工的特定缺陷导致的,可以通过DNMS任务来证明。为此,我们比较了20位OCD患者和20位人口统计学匹配的健康对照者的DNMS表现。如预期的那样,我们的结果表明,在DNMS任务下,OCD患者的表现比健康对照组差。为了测试这种行为障碍的特异性,我们还比较了强迫症患者和健康受试者在不直接涉及外侧OFC的其他任务上:延迟匹配样本任务(DMS)。不出所料 与健康受试者相比,OCD患者在DNMS和DMS任务方面的受损更大。此外,从统计学上来说,强迫症患者对DNMS任务的表现要比对DMS任务的表现差。我们的结果表明,DNMS任务专门针对OCD中的故障区域,例如横向OFC。鉴于这些结果,外侧OFC应因此成为未来治疗干预的重点。
更新日期:2019-12-11
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