当前位置: X-MOL 学术Transl. Psychiaty › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Childhood stress impairs social function through AVP-dependent mechanisms.
Translational Psychiatry ( IF 6.8 ) Pub Date : 2019-12-09 , DOI: 10.1038/s41398-019-0678-0
Nichola M Brydges 1 , Jessica Hall 2 , Caroline Best 1 , Lowenna Rule 1 , Holly Watkin 1 , Amanda J Drake 3 , Catrin Lewis 2 , Kerrie L Thomas 1, 4 , Jeremy Hall 1, 5
Affiliation  

Impaired social function is a core feature of many psychiatric illnesses. Adverse experiences during childhood increase risk for mental illness, however it is currently unclear whether stress early in life plays a direct role in the development of social difficulties. Using a rat model of pre-pubertal stress (PPS), we investigated effects on social behaviour, oxytocin and arginine vasopressin (AVP) in the periphery (plasma) and centrally in the paraventricular and supraoptic hypothalamic nuclei. We also explored social performance and AVP expression (plasma) in participants with borderline personality disorder (BPD) who experienced a high incidence of childhood stress. Social behaviour was impaired and AVP expression increased in animals experiencing PPS and participants with BPD. Behavioural deficits in animals were rescued through administration of the AVPR1a antagonist Relcovaptan (SR49059). AVP levels and recognition of negative emotions were significantly correlated in BPD participants only. In conclusion, early life stress plays a role in the precipitation of social dysfunction, and AVP mediates at least part of this effect.

中文翻译:

童年压力通过依赖AVP的机制损害社会功能。

社会功能受损是许多精神疾病的核心特征。童年时期的不良经历增加了患精神疾病的风险,但是目前尚不清楚生活中的压力是否在社会困难的发展中起直接作用。使用青春期前压力(PPS)的大鼠模型,我们研究了对社交行为,催产素和精氨酸加压素(AVP)在外围(血浆)以及中央在室旁和视上丘脑下核的影响。我们还探讨了边缘性人格障碍(BPD)参与者的童年压力高发生率,其社交表现和AVP表达(血浆)。在经历PPS的动物和BPD参与者中,社交行为受损且AVP表达增加。通过给予AVPR1a拮抗剂Relcovaptan(SR49059)可以挽救动物的行为缺陷。仅在BPD参与者中,AVP水平和对负面情绪的识别显着相关。总之,早期生活压力在社交功能障碍的加剧中起一定作用,而AVP至少可以介导这种作用。
更新日期:2019-12-11
down
wechat
bug