Epigenetic modulation can affect the characteristics of cancers. Because it is likely to manipulate epigenetic genes, they can be considered as potential targets for cancer treatment. In this comprehensive study, epigenetic drugs are categorized according to anticancer mechanisms and phase of therapy. The relevant articles or databases were searched for epigenetic approaches to cancer therapy. Epigenetic drugs are divided according to their mechanisms and clinical phases that have been approved by the FDA or are undergoing evaluation phases. DNA methylation agents, chromatin remodelers specially HDACs, and noncoding RNAs especially microRNAs are the main epi-drugs for cancer. Despite many challenges, combination therapy using epi-drugs and routine therapies such as chemotherapy in various approaches have exhibited beneficial effects compared with each treatment alone. Cancer stem cell targeting and epigenetic editing have been confirmed as definitive pathways for cancer treatment. This paper reviewed the available epigenetic approaches to cancer therapy.

表观遗传调控可影响癌症的特征。由于它很可能操纵表观遗传基因，因此可以将它们视为癌症治疗的潜在靶标。在这项综合研究中，根据抗癌机制和治疗阶段对表观遗传药物进行了分类。搜索相关文章或数据库以寻找表观遗传学方法治疗癌症。表观遗传药物根据其机制和已被FDA批准或正在评估阶段的临床阶段进行划分。DNA甲基化剂，染色质重塑剂（特别是HDAC）和非编码RNA（尤其是microRNA）是治疗癌症的主要药物。尽管面临许多挑战，与单独使用每种疗法相比，采用Epi药物进行的联合疗法和常规疗法（如化学疗法）采用各种方法已显示出有益的效果。癌症干细胞靶向和表观遗传编辑已被确认为癌症治疗的最终途径。本文综述了可用于癌症治疗的表观遗传学方法。