当前位置: X-MOL 学术Adv. Healthcare Mater. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Reactive Oxygen Species-Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disk Degeneration.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-12-10 , DOI: 10.1002/adhm.201901186
Jinyu Bai 1 , Yingzi Zhang 1 , Qin Fan 2 , Jialu Xu 2 , Huajian Shan 1 , Xiang Gao 1 , Qingle Ma 2 , Lei Sheng 1 , Xin Zheng 1 , Weinan Cheng 1 , Dazhuang Li 1 , Mingchao Zhang 1 , Yu Hao 2 , Liangzhu Feng 2 , Qian Chen 2 , Xiaozhong Zhou 1 , Chao Wang 2
Affiliation  

The chronic inflammatory microenvironment is characterized by the elevated level of reactive oxygen species (ROS). Here, it is hypothesized that developing an ROS-scavenging scaffold loaded with rapamycin (Rapa@Gel) may offer a new strategy for modulating the local inflammatory microenvironment to improve intervertebral disk tissue regeneration. The therapeutic scaffold consisting of ROS-degradable hydrogel can be injected into the injured degeneration site of intervertebral disk (IVD) and can release therapeutics in a programmed manner. The ROS scavenged by scaffold reduces the inflammatory responses. It is found that when rats are treated with Rapa@Gel, this results in an increase in the percentage of M2-like macrophages and a decrease in M1-like macrophages in the inflammatory environment, respectively. Regeneration of IVD is achieved by Rapa@Gel local treatment, due to the increased M2 macrophages and reduced inflammation. This strategy may be extended to the treatment of many other inflammatory diseases.

中文翻译:

雷帕霉素活性氧清除支架治疗椎间盘退变。

慢性炎症性微环境的特征在于活性氧(ROS)水平升高。在这里,假设开发一种载有雷帕霉素的ROS清除支架(Rapa @ Gel)可提供调节局部炎性微环境以改善椎间盘组织再生的新策略。可以将由ROS降解的水凝胶组成的治疗支架注入受伤的椎间盘(IVD)变性部位,并可以通过编程方式释放治疗剂。被支架清除的ROS减少了炎症反应。发现当用Rapa @ Gel治疗大鼠时,这分别导致在炎性环境中M2样巨噬细胞的百分比增加和M1样巨噬细胞的减少。由于M2巨噬细胞增加和炎症减少,通过Rapa @ Gel局部治疗可实现IVD的再生。该策略可以扩展到许多其他炎性疾病的治疗。
更新日期:2020-02-06
down
wechat
bug