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Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO2 for Synergistic Nucleus-Targeted NIR-II Photothermal and Hypoxia-Relieved Photodynamic Therapy.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2019-12-10 , DOI: 10.1002/adhm.201901528
Yiyi Zhang 1 , Fan Lv 2 , Yaru Cheng 1 , Zhipeng Yuan 1 , Fan Yang 1 , Conghui Liu 1 , Yu Cao 1 , Kai Zhang 1 , Huiting Lu 1 , Shah Zada 1 , Shaojun Guo 2, 3 , Haifeng Dong 1 , Xueji Zhang 1
Affiliation  

Bimetallic nanoparticles have received considerable attention owing to synergistic effect and their multifunctionality. Herein, new multifunctional Pd@Au bimetallic nanoplates decorated hollow mesoporous MnO2 nanoplates (H-MnO2 ) are demonstrated for achieving not only nucleus-targeted NIR-II photothermal therapy (PTT), but also tumor microenvironment (TME) hypoxia relief enhanced photodynamic therapy (PDT). The Pd@Au nanoplates present a photothermal conversion efficiency (PTCE) as high as 56.9%, superior to those PTAs activated in the NIR-II region such as Cu9 S5 nanoparticles (37%), Cu3 BiS3 nanorods (40.7%), and Au/Cu2- x S nanocrystals (43.2%). They further functionalize with transactivator of transcription (TAT) moiety for cell nuclear-targeting and biodegradable hollow mesoporous MnO2 (≈100 nm) loaded with photosensitizer Ce6 (TAT-Pd@Au/Ce6/PAH/H-MnO2 ) to construct a hierarchical targeting nanoplatform. The as-made TAT-Pd@Au/Ce6/PAH/H-MnO2 demonstrates good premature renal clearance escape ability and increased tumor tissue accumulation. It can be degraded in acidic TME and generate O2 by reacting to endogenous H2 O2 to relieve the hypoxia for enhanced PDT, while the released small TAT-Pd@Au nanoplates can effectively enter into the nucleus to mediate PTT. As a result, a remarkable therapeutic effect is achieved owing to the synergistic PTT/PDT therapy. This hierarchical targeting, TME-responsive, cytoplasm hypoxia relief PDT, and nuclear NIR-II PTT synergistic therapy can pave a new avenue for nanomaterials-based cancer therapy.

中文翻译:

Pd @ Au双金属纳米板装饰了介孔MnO2,用于协同核靶向NIR-II光热和缺氧缓解的光动力疗法。

双金属纳米颗粒由于协同作用和其多功能性而受到了相当大的关注。在本文中,新型多功能Pd @ Au双金属纳米板修饰的空心中孔MnO2纳米板(H-MnO2)被证明不仅可以实现针对核的NIR-II光热疗法(PTT),而且还可以实现肿瘤微环境(TME)缺氧缓解增强的光动力疗法(太平洋夏令时)。Pd @ Au纳米板的光热转换效率(PTCE)高达56.9%,优于在NIR-II区激活的PTA,例如Cu9 S5纳米颗粒(37%),Cu3 BiS3纳米棒(40.7%)和Au / Cu 2 -x S纳米晶体(43.2%)。它们进一步通过转录反式激活剂(TAT)部分进行功能化,以实现细胞核靶向,并通过可生物降解的空心中孔MnO2(≈100nm)负载光敏剂Ce6(TAT-Pd @ Au / Ce6 / PAH / H-MnO2)来构建分级靶向纳米平台。制成的TAT-Pd @ Au / Ce6 / PAH / H-MnO2表现出良好的过早肾脏清除逃逸能力和增加的肿瘤组织蓄积。它可以在酸性TME中降解并通过与内源性H2 O2反应生成O2,从而减轻缺氧,从而增强PDT,而释放的TAT-Pd @ Au纳米小板可以有效进入细胞核来介导PTT。结果,由于协同的PTT / PDT疗法,获得了显着的治疗效果。这种针对TME的,可缓解细胞质缺氧的PDT分级靶向药物,
更新日期:2020-01-23
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