Ca2+ cations play a key role in the initiation of spermatozoa motility in Atlantic salmon (Salmo salar). In this study we assess the importance of the voltage-gated L-type calcium channels in the spermatozoa motility of Atlantic salmon by combined in vitro and in silico approaches. The results of this study showed that as in other fish species, voltage-gated L-type calcium channels are significant in the spermatozoa motility of Salmo salar. The in vitro assays showed that total and progressive motilities decrease significantly (****p < .001) when Salmo salar spermatozoa are treated with verapamil, which has its binding site in the pore of the voltage-gated L-type calcium channel according to the in silico analysis.

中文翻译：

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电压门控L型钙通道在大西洋鲑（Salmo salar）精子运动中的作用。

Ca2 +阳离子在大西洋鲑（Salmo salar）的精子活动性启动中起关键作用。在这项研究中，我们通过体外和计算机模拟方法评估了电压门控L型钙通道在大西洋鲑精子运动中的重要性。这项研究的结果表明，与其他鱼类一样，电压门控的L型钙通道在Salmo salar的精子活力中也很重要。体外试验显示，当用维拉帕米治疗Salmo salar精子时，总和进行性功能显着降低（**** p <.001），其结合位点位于电压门控L型钙通道的孔中。进行计算机分析。