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Antimicrobial metabolites from the endophytic fungus Aspergillus versicolor
Phytochemistry Letters ( IF 1.7 ) Pub Date : 2019-12-10 , DOI: 10.1016/j.phytol.2019.12.003
Gamal A. Mohamed , Sabrin R.M. Ibrahim , Hani Z. Asfour

Two new diaryl ether derivatives [aspergillethers A (4) and B (5)] and five known metabolites [(22E,24R)-stigmasta-5,7,22-trien-3-β-ol (1), stigmasta-4,6,8(14),22-tetraen-3-one (2), orcinol (3), and butyrolactones I (6) and VI (7)] were separated from the endophytic fungus Aspergillus versicolor (Aspergillaceae) isolated from the roots of Pulicaria crispa Forssk (Asteraceae) growing in Saudi Arabia. The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and HRESIMS) and by comparison with the literature data. Compounds 4 and 5 were evaluated for their antimicrobial properties towards different microorganisms using a disc diffusion assay. Compound 5 exhibited significant antibacterial capacity towards Staphylococcus aureus, Bacillus cereus, and Escherichia coli with inhibition zone diameters (IZDs) of 14.3, 19.8, and 24.5 mm, respectively, and MICs values of 4.3, 3.7, and 3.9 μg/mL, respectively, compared to ciprofloxacin (MICs 3.1, 2.8, and 3.5 μg/mL, respectively). In addition, compound 5 exhibited prominent antifungal activity towards Candida albicans and Geotrichium candidum (IZDs 15.8 mm and 17.5 mm, respectively) in comparison to that of clotrimazole (IZDs 17.2 mm and 21.4 mm, respectively).



中文翻译:

内生真菌杂色曲霉的抗菌代谢物

两个新的二芳基醚衍生物[aspergillethers A(4)和B(5)]和五个已知的代谢物[(22 E,24 R)-stigmasta-5,7,22-trien-3-β-ol(1),stigmasta -4,6,8(14),22-tetraen-3-one(2),orcinol(3)和丁内酯I(6)和VI(7)]从分离的内生真菌杂色曲霉(Aspergillusceae)中分离从Pullicaria crispa的根源Forssk(菊科)在沙特阿拉伯生长。这些化合物的结构通过各种光谱技术(例如UV,IR,NMR和HRESIMS)确定,并与文献数据进行比较。使用盘扩散测定法评价化合物45对不同微生物的抗微生物特性。化合物5金黄色葡萄球菌蜡状芽孢杆菌大肠杆菌表现出显着的抗菌能力。与环丙沙星相比,抑菌圈直径(IZDs)分别为14.3、19.8和24.5 mm,MIC值分别为4.3、3.7和3.9μg/ mL(MIC分别为3.1、2.8和3.5μg/ mL )。此外,化合物5显示出朝向突出的抗真菌活性白色念珠菌Geotrichium石斛相较于克霉唑(IZDs分别15.8毫米和17.5毫米,)(IZDs分别17.2毫米和21.4毫米,)。

更新日期:2019-12-11
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