Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.,Neuron

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Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.
Neuron ( IF 16.2 ) Pub Date : 2019-12-10 , DOI: 10.1016/j.neuron.2019.11.012
Deanna J Greene ₁ , Scott Marek ₂ , Evan M Gordon ₃ , Joshua S Siegel ₄ , Caterina Gratton ₅ , Timothy O Laumann ₄ , Adrian W Gilmore ₆ , Jeffrey J Berg ₇ , Annie L Nguyen ₂ , Donna Dierker ₈ , Andrew N Van ₂ , Mario Ortega ₂ , Dillan J Newbold ₂ , Jacqueline M Hampton ₄ , Ashley N Nielsen ₉ , Kathleen B McDermott ₁₀ , Jarod L Roland ₆ , Scott A Norris ₂ , Steven M Nelson ₃ , Abraham Z Snyder ₁₁ , Bradley L Schlaggar ₁₂ , Steven E Petersen ₁₃ , Nico U F Dosenbach ₁₄

Affiliation

Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
VISN17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Department of Psychology, Northwestern University, Evanston, IL, USA; Department of Neurology, Northwestern University, Evanston, IL, USA.
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Department of Psychology, New York University, New York, NY, USA.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Institute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, USA.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychological and Brain Sciences, Washington University, St. Louis, MO, USA.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Program in Occupational Therapy, Washington University, St. Louis, MO, USA.

The basal ganglia, thalamus, and cerebral cortex form an interconnected network implicated in many neurological and psychiatric illnesses. A better understanding of cortico-subcortical circuits in individuals will aid in development of personalized treatments. Using precision functional mapping-individual-specific analysis of highly sampled human participants-we investigated individual-specific functional connectivity between subcortical structures and cortical functional networks. This approach revealed distinct subcortical zones of network specificity and multi-network integration. Integration zones were systematic, with convergence of cingulo-opercular control and somatomotor networks in the ventral intermediate thalamus (motor integration zones), dorsal attention and visual networks in the pulvinar, and default mode and multiple control networks in the caudate nucleus. The motor integration zones were present in every individual and correspond to consistently successful sites of deep brain stimulation (DBS; essential tremor). Individually variable subcortical zones correspond to DBS sites with less consistent treatment effects, highlighting the importance of PFM for neurosurgery, neurology, and psychiatry.

中文翻译：

个体定义的基底神经节和丘脑的整合和特定于网络的连通性。

基底神经节，丘脑和大脑皮层形成相互联系的网络，牵涉到许多神经和精神疾病。更好地了解个体的皮质-皮层下回路将有助于个性化治疗的发展。使用精确的功能映射-高度采样的人类参与者的个人特定分析-我们研究了皮层下结构与皮质功能网络之间的特定于个人的功能连接。这种方法揭示了网络特异性和多网络集成的不同皮层下区域。整合区是系统的，在腹中丘脑（运动整合区），背侧注意力和视觉网络（在大脑丘脑中部）上有扣带-操作控制和躯体运动网络的融合，尾核中的默认模式和多个控制网络。运动整合区存在于每个人中，并对应于持续的深部脑刺激成功部位（DBS；基本震颤）。个体可变的皮层下区域对应于DBS部位，治疗效果较差，突显了PFM在神经外科，神经病学和精神病学中的重要性。

更新日期：2019-12-11

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