Carcinogen-induced cancers typically have high mutation burdens and an inflamed microenvironment and thus are poised to respond to immune checkpoint inhibitors (ICIs). However, cancers with loss-of-function mutations in the SWI/SNF complex have few additional mutations yet also have an inflamed immunophenotype and should respond to ICI therapy.

中文翻译：

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感冒时：对横纹肌瘤的免疫检查点抑制疗法。

致癌物诱发的癌症通常具有较高的突变负担和微环境发炎的状况，因此有望对免疫检查点抑制剂（ICI）做出反应。但是，在SWI / SNF复合物中功能丧失突变的癌症几乎没有其他突变，但免疫表型却发炎，应该对ICI治疗产生反应。