Spliceosomes comprise small nuclear (sn)RNAs and proteins. Through genome-wide analyses in large-scale tumor samples, recent studies by Shuai et al., Suzuki et al., and Inoue et al. have identified recurrent spliceosomal mutations that induced genome-wide splicing alterations of cancer-related genes to promote malignancy. These discoveries suggest novel RNA-based therapeutics in anticancer treatment.

中文翻译：

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解决剪接体功能障碍促进了基于RNA的治疗方法的发展。

剪接体包含小核（sn）RNA和蛋白质。通过对大规模肿瘤样本进行全基因组分析，Shuai等人，Suzuki等人和Inoue等人的最新研究表明了这种方法。已经鉴定出可导致癌症相关基因的全基因组剪接改变以促进恶性的复发性剪接体突变。这些发现表明在抗癌治疗中新的基于RNA的疗法。