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Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.tins.2019.11.001
Chinnakkaruppan Adaikkan 1 , Li-Huei Tsai 2
Affiliation  

Studies have shown that gamma oscillations (30-100 Hz) are relevant for neurocircuit function, behavior, and memory. To examine a possible causal contribution of gamma oscillations to cognitive function, recent studies have employed various types of brain stimulation to induce gamma oscillations. Techniques such as optogenetics or sensory stimulation appear to engage canonical neurocircuits that encompass excitatory and inhibitory interneurons, similarly to those driven by sensory experience, to induce gamma entrainment. Sensory evoked gamma entrainment improves cognitive function in mouse models. Oscillations have traditionally been studied at the neurophysiological level; however, sensory evoked gamma entrainment is able to induce gene expression changes in multiple cell types including neurons and microglia. Furthermore, evidence suggests that chronic gamma entrainment offers neuroprotective effects.

中文翻译:

伽马夹带:对神经回路、神经胶质和治疗机会的影响

研究表明,伽马振荡 (30-100 Hz) 与神经回路功能、行为和记忆有关。为了检查伽马振荡对认知功能的可能因果贡献,最近的研究采用了各种类型的脑刺激来诱导伽马振荡。光遗传学或感觉刺激等技术似乎参与了包含兴奋性和抑制性中间神经元的经典神经回路,类似于那些由感官体验驱动的技术,以诱导伽马夹带。感官诱发的伽马夹带可改善小鼠模型的认知功能。传统上,振荡是在神经生理学水平上进行研究的。然而,感觉诱发的伽马夹带能够诱导多种细胞类型的基因表达变化,包括神经元和小胶质细胞。此外,
更新日期:2020-01-01
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