Carbohydrate molecules are essential actors in key biological events, being involved as recognition points for cell-cell and cell-matrix interactions related to health and disease. Despite outstanding advances in cryoEM, X-ray crystallography and NMR still remain the most employed techniques to unravel their conformational features and to describe the structural details of their interactions with biomolecular receptors. Given the intrinsic flexibility of saccharides, NMR methods are of paramount importance to deduce the extent of motion around their glycosidic linkages and to explore their receptor-bound conformations. We herein present our particular view on the latest advances in NMR methodologies that are permitting to magnify their applications for deducing glycan conformation and dynamics and understanding the recognition events in which there are involved.

中文翻译：

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聚糖结构及其与蛋白质的相互作用。NMR视图。

碳水化合物分子是关键生物学事件中的重要角色，被作为与健康和疾病相关的细胞-细胞和细胞-基质相互作用的识别点。尽管cryoEM取得了显着进步，但X射线晶体学和NMR仍然是最常用的技术，以揭示其构象特征并描述其与生物分子受体相互作用的结构细节。考虑到糖类固有的柔韧性，NMR方法对于推断糖苷键周围的运动范围并探索其受体结合构象至关重要。