Bis-BINOL derivatives have proven highly useful in applications such as chemosensing or organocatalysis. In this account, we describe strategies for the linking of BINOL units via the 3-, 4-, or 5-positions, showing that unique synthetic strategies are necessary to address each position. We report the synthesis of suitable C ₁-symmetric precursors, which are generated either by monohalogenation or by monodeprotection of C ₂-symmetric starting materials, and their subsequent coupling to give linked bis-BINOL derivatives.

中文翻译：

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Bis-BINOL衍生物的合成：通过生成合适的C 1对称前体，通过3位，4位或5位连接

已证明Bis-BINOL衍生物在化学传感或有机催化等应用中非常有用。在此说明中，我们描述了通过3位，4位或5位BINOL单元连接的策略，表明独特的合成策略对于解决每个位置都是必要的。我们报道了合适的C _1-对称前体的合成，其通过C _2-对称起始原料的单卤代反应或通过单脱保护而产生，并且其随后偶联以产生连接的双-BINOL衍生物。