Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele,Alzheimer's & Dementia

当前位置： X-MOL 学术 › Alzheimers Dement. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2020-04-01 , DOI: 10.1016/j.jalz.2019.08.195
Valentina Ghisays _{1,

2} , Dhruman D Goradia _{1,

2} , Hillary Protas _{1,

2} , Robert J Bauer _{1,

2} , Vivek Devadas _{1,

2} , Pierre N Tariot _{1,

2,

3} , Val J Lowe ₄ , David S Knopman ₅ , Ronald C Petersen ₅ , Clifford R Jack ₄ , Richard J Caselli _{2,

6} , Yi Su _{1,

2} , Kewei Chen _{1,

2,

3,

7} , Eric M Reiman _{1,

2,

3,

7,

8}

Affiliation

We previously characterized associations between brain imaging measurements of amyloid‐β (Aβ) plaque burden and apolipoprotein E (APOE) ε4 gene dose in a small number of cognitively unimpaired late‐middle‐aged APOE ε4 homozygotes (HMs), heterozygotes (HTs), and noncarriers (NCs). We now characterize cross‐sectional Aβ plaque, tau tangle, and cortical atrophy (neurodegeneration) measurements, classifications, and associations with age in a larger number of unimpaired HMs, HTs, and NCs over a wider age range.

中文翻译：

具有两个、一个和没有 APOE ε4 等位基因拷贝的认知未受损者的纤维状淀粉样蛋白 β 负荷、成对螺旋丝 tau 负荷和萎缩的脑成像测量

我们之前在少量认知未受损的中晚期 APOE ε4 纯合子 (HMs)、杂合子 (HTs)、和非携带者 (NC)。我们现在在更广泛的年龄范围内对大量未受损 HM、HT 和 NC 的横截面 Aβ 斑块、tau 缠结和皮质萎缩（神经变性）测量、分类和与年龄的关联进行表征。

更新日期：2020-04-01

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文

全部期刊列表>>