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Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers.
Soft Matter ( IF 3.4 ) Pub Date : 2019-12-18 , DOI: 10.1039/c9sm01642b Jing Yu 1 , Jun Mao 1 , Michihiro Nagao 2 , Wei Bu 3 , Binhua Lin 4 , Kunlun Hong 5 , Zhang Jiang 6 , Yun Liu 7 , Shuo Qian 8 , Matthew Tirrell 1 , Wei Chen 1
Soft Matter ( IF 3.4 ) Pub Date : 2019-12-18 , DOI: 10.1039/c9sm01642b Jing Yu 1 , Jun Mao 1 , Michihiro Nagao 2 , Wei Bu 3 , Binhua Lin 4 , Kunlun Hong 5 , Zhang Jiang 6 , Yun Liu 7 , Shuo Qian 8 , Matthew Tirrell 1 , Wei Chen 1
Affiliation
The structure and dynamics of lipid membranes in the presence of extracellular macromolecules are critical for cell membrane functions and many pharmaceutical applications. The pathogen virulence-suppressing end-phosphorylated polyethylene glycol (PEG) triblock copolymer (Pi-ABAPEG) markedly changes the interactions with lipid vesicle membranes and prevents PEG-induced vesicle phase separation in contrast to the unphosphorylated copolymer (ABAPEG). Pi-ABAPEG weakly absorbs on the surface of lipid vesicle membranes and slightly changes the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) unilamellar vesicles at 37 °C, as evidenced by small angle neutron scattering. X-ray reflectivity measurements confirm the weak adsorption of Pi-ABAPEG on DMPC monolayer, resulting in a more compact DMPC monolayer structure. Neutron spin-echo results show that the adsorption of Pi-ABAPEG on DMPC vesicle membranes increases the membrane bending modulus κ.
中文翻译:
脂质膜与抗毒性的末端磷酸化聚乙二醇嵌段共聚物相互作用的结构和动力学。
存在细胞外大分子时脂质膜的结构和动力学对于细胞膜功能和许多药物应用至关重要。与未磷酸化的共聚物(ABAPEG)相比,病原体抑制毒力的末端磷酸化的聚乙二醇(PEG)三嵌段共聚物(Pi-ABAPEG)显着改变了与脂质囊泡膜的相互作用,并阻止了PEG诱导的囊泡相分离。Pi-ABAPEG在37°C下微弱地吸附在脂质囊泡膜的表面上,并稍微改变1,2-二肉豆蔻酰基-sn-甘油-3-磷酸胆碱(DMPC)单层囊泡的结构,这通过小角度中子散射得以证明。X射线反射率测量结果证实Pi-ABAPEG在DMPC单层上的吸附较弱,从而导致DMPC单层结构更加紧凑。
更新日期:2020-02-10
中文翻译:
脂质膜与抗毒性的末端磷酸化聚乙二醇嵌段共聚物相互作用的结构和动力学。
存在细胞外大分子时脂质膜的结构和动力学对于细胞膜功能和许多药物应用至关重要。与未磷酸化的共聚物(ABAPEG)相比,病原体抑制毒力的末端磷酸化的聚乙二醇(PEG)三嵌段共聚物(Pi-ABAPEG)显着改变了与脂质囊泡膜的相互作用,并阻止了PEG诱导的囊泡相分离。Pi-ABAPEG在37°C下微弱地吸附在脂质囊泡膜的表面上,并稍微改变1,2-二肉豆蔻酰基-sn-甘油-3-磷酸胆碱(DMPC)单层囊泡的结构,这通过小角度中子散射得以证明。X射线反射率测量结果证实Pi-ABAPEG在DMPC单层上的吸附较弱,从而导致DMPC单层结构更加紧凑。