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Chemical and biological evaluation of cross-linked halloysite-curcumin derivatives
Applied Clay Science ( IF 5.6 ) Pub Date : 2020-01-01 , DOI: 10.1016/j.clay.2019.105400
Marina Massaro , Paola Poma , Carmelo G. Colletti , Anna Barattucci , Paola M. Bonaccorsi , Giuseppe Lazzara , Giuseppe Nicotra , Filippo Parisi , Tania M.G. Salerno , Corrado Spinella , Serena Riela

Abstract Well designed and safe nano drug carrier systems are an important tool in biomedical applications. The combination of two or more drugs has been used in medicine both to enhance the therapeutic effect and to decrease the side effects of drugs. Biocompatible halloysite nanotubes, that possess two different surfaces, are a suitable nanomaterial for a simultaneous carrier and release of two drugs that can exert a synergistic effect against cancer cells. In this study, three curcumin derivatives and doxorubicin were loaded by supramolecular and covalent linkage at the lumen and external surface of the halloysite nanotubes. The obtained multifunctional systems were characterized by several techniques and the kinetic release of the drugs from the lumen was also investigated. Finally, the cytotoxic effects of the multifunctional carriers were evaluated on different cancer cell lines, namely breast cancer cell lines (SUM-149 and MDA-MB-231) and acute myeloid leukemia cell lines (HL60 and HL60R). The obtained results show promising cytotoxicity activity of the hybrids which is correlated to the nanoparticles size and to the release profile of the drug supramolecularly loaded on Hal surfaces.

中文翻译:

交联埃洛石-姜黄素衍生物的化学和生物学评价

摘要 精心设计且安全的纳米药物载体系统是生物医学应用中的重要工具。两种或多种药物的组合已在医学上用于增强治疗效果和减少药物的副作用。具有两个不同表面的生物相容性埃洛石纳米管是一种合适的纳米材料,可同时载体和释放两种药物,可以对癌细胞产生协同作用。在这项研究中,三种姜黄素衍生物和阿霉素通过超分子和共价键连接在埃洛石纳米管的内腔和外表面。获得的多功能系统通过多种技术进行表征,并且还研究了药物从管腔中的动力学释放。最后,多功能载体对不同癌细胞系的细胞毒作用进行了评估,即乳腺癌细胞系(SUM-149 和 MDA-MB-231)和急性髓系白血病细胞系(HL60 和 HL60R)。获得的结果显示了杂化物的有希望的细胞毒性活性,这与纳米颗粒尺寸和装载在 Hal 表面上的超分子药物的释放曲线相关。
更新日期:2020-01-01
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