A novel indicator, childhood lipid accumulation product, is associated with hypertension in Chinese children and adolescents,Hypertension Research

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A novel indicator, childhood lipid accumulation product, is associated with hypertension in Chinese children and adolescents
Hypertension Research ( IF 5.4 ) Pub Date : 2019-12-09 , DOI: 10.1038/s41440-019-0366-8
Yuan Wang ₁ , Wenmin Liu ₁ , Lili Sun ₁ , Yifei Zhang ₁ , Bangxuan Wang ₁ , Yongting Yuan ₁ , Ting Li ₁ , Rongying Yao ₁ , Hui Han ₁ , Qingwen Qian ₂ , Lianguo Fu ₁

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Childhood hypertension has become an important public health issue. This study explored a novel indicator, namely, childhood lipid accumulation product (CLAP), which is associated with hypertension among children and adolescents. A total of 683 children and adolescents aged 8–15 years were measured for body weight, height, waist circumference (WC), abdominal skinfold thickness (AST), triacylglycerol (TG), blood pressure, dietary behaviors, and physical activity time. The novel childhood lipid accumulation product (CLAP) was the product of WC, AST, and TG (CLAP = WC (cm) × AST (mm) × TG (mmol/L)). The logarithmic CLAP (LnCLAP), height, weight, WC, WHtR, BMI, AST, and TG were standardized for sex and age using the z -score method (standardized variables: SLnCLAP, Sheight, Sweight, SWC, SWHtR, SBMI, SAST, and STG). The results showed that the overall prevalence of hypertension was 11.6% (13.1% in boys and 9.7% in girls). SLnCLAP ≥ 1, Sweight ≥ 1, SWC ≥ 1, SWHtR ≥ 1, SBMI ≥ 1, SAST ≥ 1, and STG ≥ 1 increased the statistical risk of childhood hypertension (odds ratio values (95% CI) were 3.70 (2.22–6.16), 2.58 (1.50–4.43), 3.08 (1.84–5.15), 2.33 (1.38–3.93), 2.96 (1.72–5.29), 2.38 (1.41–4.70), and 2.40 (1.38–4.19), respectively). The area under the ROC curve (AUC) for CLAP was higher than that for weight, WC, WHtR, BMI, AST, and TG in the prediction of hypertension. In conclusion, this study showed that CLAP is a novel indicator associated with hypertension in children and adolescents and can more effectively predict childhood hypertension than weight, WC, WHtR, BMI, AST, and TG can.

更新日期：2019-12-09

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