As a continual source of sensory input and fundamental component of self-referential processing, the body holds an integral modulatory role in cognition. In a healthy state, predictive coding of multisensory integration promotes the construction of a coherent self. However, several psychiatric disorders comprise aberrant perceptions of the bodily self that are purported to involve discrepancies in the integration and updating of multisensory systems. Changes in functional connectivity of somatomotor and high-level association networks in these disorders could be successfully remediated through 5-HT2A receptor agonism via psychedelics. Reported alterations of bodily self-awareness during psychedelic experiences allude to a potentially central role of the bodily self. In this article, we bridge the domains of (aberrant) bodily self-awareness and psychedelics by discussing the predictive coding mechanisms underlying the bodily self and psychedelics. Furthermore, we propose that psychedelically-induced desynchronization of predictive coding might involve modulation of somatomotor, sensorimotor, and high-level association networks that could remediate aberrant perceptions of the bodily self.

中文翻译：

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通过迷幻剂对异常自我进行神经药理学调节。

作为感觉输入的持续来源和自我参照处理的基本组成部分，身体在认知中起着不可或缺的调节作用。在健康状态下，多感觉整合的预测编码促进了连贯自我的建构。但是，一些精神疾病包括对身体自我的异常感知，据称涉及多感官系统的集成和更新中的差异。在这些疾病中，躯体运动和高级关联网络的功能连通性变化可以通过迷幻药通过5-HT2A受体激动剂成功地修复。据报道，在迷幻经历中身体自我意识的改变暗示着身体自我的潜在核心作用。在本文中，我们通过讨论潜在的身体自我和迷幻的编码机制来桥接（异常）身体自我意识和迷幻的领域。此外，我们建议心理上引起的预测编码失步可能涉及对体动，感觉运动和高级关联网络的调制，这些网络可以纠正身体自我的异常认识。