当前位置: X-MOL 学术ACS Med. Chem. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Radioiodinated Nitroxide Derivative for the Detection of Lipid Radicals.
ACS Medicinal Chemistry Letters ( IF 4.2 ) Pub Date : 2019-12-03 , DOI: 10.1021/acsmedchemlett.9b00416
Toshihide Yamasaki 1 , Risa Azuma 1 , Kohei Sano 1 , Masayuki Munekane 1 , Yuta Matsuoka 2 , Ken-Ichi Yamada 2, 3 , Takahiro Mukai 1
Affiliation  

Thus far, no accurate measurement technology has been developed to detect lipid alkyl radicals (lipid radicals), which cause lipid peroxidation. Therefore, we aimed to develop a nuclear medical imaging probe that can be taken up in the lipophilic site in cells such as biological membranes, by reacting specifically with the lipid radicals generated there. We designed and synthesized 4-(4-[125I]iodobenzamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, which shows high reactivity to lipid radicals with a high radiochemical yield and purity. Intracellular retention was found to increase significantly when lipid radicals were produced.

中文翻译:

放射性碘标记的一氧化二氮衍生物,用于脂质自由基的检测。

迄今为止,还没有开发出精确的测量技术来检测引起脂质过氧化的脂质烷基自由基(脂质自由基)。因此,我们旨在开发一种核医学成像探针,该探针可通过与在那里产生的脂质自由基特异性反应而被吸收在细胞(如生物膜)的亲脂位点中。我们设计并合成了4-(4- [125I] iodobenzamido)-2,2,6,6-四甲基哌啶-1-氧基,该化合物对脂质自由基具有高反应活性,并具有较高的放射化学收率和纯度。当产生脂质自由基时,发现细胞内保留显着增加。
更新日期:2019-12-07
down
wechat
bug