CF₃S, CF₃ and HCF₂ groups have been identified as valuable functionalities for drug development. Despite significant accomplishments in the trifluoromethylthiolation, trifluoromethylation and difluoromethylation reactions, directly converting common functional groups into CF₃S, CF₃ or HCF₂ groups is still highly desirable. Described here is the dehydroxylative trifluoromethylthiolation, trifluoromethylation and difluoromethylation of alcohols promoted by a R₃P/ICH₂CH₂I system. All of these dehydroxylative reactions were achieved under mild conditions via the activation of the hydroxyl group by the R₃P/ICH₂CH₂I system. A wide substrate scope and good functional group tolerance were observed.

中文翻译：

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醇的脱羟基三氟甲基硫醇化，三氟甲基化和二氟甲基化

CF ₃ S，CF ₃和HCF ₂基团已被确定为药物开发的有价值的功能。尽管在三氟甲基硫醇化，三氟甲基化和二氟甲基化反应方面取得了重大成就，仍然非常需要将常见的官能团直接转化为CF ₃ S，CF ₃或HCF ₂基团。在此描述的是由R ₃ P / ICH ₂ CH ₂ I体系促进的醇的脱羟基三氟甲基硫醇化，三氟甲基化和二氟甲基化。所有这些脱羟基反应都是在温和条件下通过R活化羟基而实现的₃ P / ICH ₂ CH ₂ I系统。观察到较宽的底物范围和良好的官能团耐受性。