Double hydrothiolation of bis enol ether macrocycles was achieved under photo-mediated conditions. The thiol-ene reactions afford a fully regioselective anti-Markovnikov post-functionalization. Thanks to the use of ethanedithiol as reagent, moderate to excellent diastereoselectivity was accomplished leading to macrocycles containing four defined stereocenters in only three steps from 1,4-dioxane, tetrahydrofuran (THF) or tetrahydropyran (THP).

中文翻译：

---

用于不饱和聚醚大环化合物后期官能化的光诱导硫醇-烯反应：区域和非对映选择性进入大环二硫醇衍生物。

双烯醇醚大环的双氢硫醇化在光介导的条件下实现。硫醇-烯反应提供了完全区域选择性的反马尔科夫尼科夫后功能化。由于使用了乙二硫醇作为试剂，因此实现了中度至出色的非对映选择性，从而使大环在三个步骤中仅由1,4-二恶烷，四氢呋喃（THF）或四氢吡喃（THP）包含四个定义的立体中心。