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Association between polymorphisms of cytokine genes and brucellosis: A comprehensive systematic review and meta-analysis
Cytokine ( IF 3.8 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.cyto.2019.154949
Parisa Zafari 1 , Ahmadreza Zarifian 2 , Reza Alizadeh-Navaei 3 , Mahdi Taghadosi 4 , Alireza Rafiei 5
Affiliation  

OBJECTIVE Owing to involvement of host genetic factors in susceptibility to brucellosis infection and its outcome, this study aimed to carry out a comprehensive systematic review and meta-analysis to derive a precise evaluation of the association between the risk of brucellosis and its focal complication and all cytokines examined in case-control studies, including Interferon gamma (IFN-γ), Tumor Necrosis Factor (TNF)-α, TNF-β, Transforming Growth Factor(TGF)-β, IL-2, IL-4, IL-6, IL-10, IL-12B, IL-15, and IL-18 polymorphisms. METHODS A systematic literature search in PubMed, Web of Science, Google Scholar, and Scopus was performed to identify the relevant studies, and related information was extracted. The effect size (ES) and corresponding 95% confidence intervals (CIs) were calculated to estimate the association. RESULTS From 158 initial results, twenty-five eligible studies were included in the meta-analysis. Overall, the pooled results showed that the dominant models of IFN-γ UTR5644, TGF-β rs1800470 and rs1800471, TNF-α rs1800629, and IL-10 rs1800872 were significantly less frequent in brucellosis patients than the controls. Also, the pooled analysis of the mutant allele vs. wild allele of TGF-β rs1800471 and IL-10 rs1800872 showed negative association with brucellosis risk. On the other hand, our pooled analysis demonstrated that the mutant allele of IL-4 rs2243250 and IL-18 rs1946519 were associated with increased susceptibility to brucellosis. In addition, the IFN-γ UTR5644 and TGF-β rs1800470 were more frequent in the patients without focal forms. CONCLUSIONS IL-4 rs2243250 and IL-18 rs1946519 have a positive correlation with brucellosis whereas the IFN-γ UTR5644, TGF-β rs1800470 and rs1800471, TNF-α rs1800629, and IL-10 rs1800872 showed a negative association with this disease. The association between the other single nucleotide polymorphisms (SNP) and brucellosis risk was not confirmed in the current meta-analysis. PROSPERO Registration: CRD42018117203.

中文翻译:

细胞因子基因多态性与布鲁氏菌病的关联:综合系统评价和荟萃分析

目的 由于宿主遗传因素参与布鲁氏菌病感染的易感性及其结果,本研究旨在进行全面的系统评价和荟萃分析,以准确评估布鲁氏菌病风险与其局灶性并发症和所有疾病之间的关联。在病例对照研究中检测的细胞因子,包括干扰素 γ (IFN-γ)、肿瘤坏死因子 (TNF)-α、TNF-β、转化生长因子 (TGF)-β、IL-2、IL-4、IL-6 、IL-10、IL-12B、IL-15 和 IL-18 多态性。方法通过PubMed、Web of Science、Google Scholar、Scopus系统检索文献,识别相关研究,提取相关信息。计算效应量 (ES) 和相应的 95% 置信区间 (CI) 以估计关联。结果 从 158 个初步结果中,25 项符合条件的研究被纳入荟萃分析。总体而言,汇总结果表明,布鲁氏菌病患者中 IFN-γ UTR5644、TGF-β rs1800470 和 rs1800471、TNF-α rs1800629 和 IL-10 rs1800872 的主要模型显着低于对照组。此外,对 TGF-β rs1800471 和 IL-10 rs1800872 的突变等位基因与野生等位基因的汇总分析显示与布鲁氏菌病风险呈负相关。另一方面,我们的汇总分析表明,IL-4 rs2243250 和 IL-18 rs1946519 的突变等位基因与布鲁氏菌病易感性增加有关。此外,在没有局灶形式的患者中,IFN-γ UTR5644 和 TGF-β rs1800470 更常见。结论 IL-4 rs2243250 和 IL-18 rs1946519 与布鲁氏菌病呈正相关,而 IFN-γ UTR5644、TGF-β rs1800470 和 rs1800471、TNF-α rs1800629 和 IL-10 rs1800872 与该疾病呈负相关。目前的荟萃分析未证实其他单核苷酸多态性 (SNP) 与布鲁氏菌病风险之间的关联。PROSPERO 注册号:CRD42018117203。
更新日期:2020-03-01
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