Human induced pluripotent stem cells (iPSCs) that express stable and robust fluorescent proteins have proven to be indispensable in basic and translational research. These reporter iPSC lines can greatly facilitate cell imaging, sorting, and tracking in vitro and in vivo studies. Here, we document two reporter human iPSC lines generated by gene-editing technologies that precisely integrated one-copy of a tdTomato transgene driven by strong CAG promoter into the AAVS1 human safe harbor locus.

中文翻译：

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通过AAVS1安全港基因编辑生成两个tdTomato报告基因诱导的多能干细胞系（NHLBIi003-A-1和NHLBIi003-A-2）。

表达稳定和强健的荧光蛋白的人诱导多能干细胞（iPSC）已被证明在基础研究和翻译研究中必不可少。这些报道iPSC系可以大大方便细胞成像，排序和跟踪在体外和体内研究。在这里，我们记录了由基因编辑技术生成的两个报告基因人类iPSC系，这些基因将由强CAG启动子驱动的tdTomato转基因的单拷贝精确整合到AAVS1人类安全港所在地。