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Effects of fish oil supplement on psoriasis: a meta-analysis of randomized controlled trials.
BMC Complementary and Alternative Medicine ( IF 4.782 ) Pub Date : 2019-12-05 , DOI: 10.1186/s12906-019-2777-0
Shih-Jyun Yang , Ching-Chi Chi

BACKGROUND Fish oils, which contain omega-3 polyunsaturated fatty acids as the active ingredients, possess anti-inflammatory activities and may have therapeutic potential in diseases with an inflammatory etiology. Fish oil supplement has been advocated for treating psoriasis which is a chronic inflammatory dermatosis. OBJECTIVE We aimed to investigate the effects of fish oil supplement on psoriasis. METHODS We searched CENTRAL, Embase and MEDLINE on 24 January 2018 for randomized control trials (RCTs) on the effects of fish oil supplement in treating psoriasis. The Cochrane Collaboration's tool was used to assess the risk of bias of included RCTs. We performed a random-effects model meta-analysis to obtain the pooled treatment effect estimates. RESULTS We included 13 RCTs with 625 participants. Three RCTs involving 337 participants provided usable data for meta-analysis. Fish oil supplement did not significantly reduce the severity of psoriasis when assessed by Psoriasis Area and Severity Index score (mean difference - 0.28; 95% confidence interval - 1.74 to 1.19). CONCLUSION The current evidence does not support the use of fish oil supplement in treating psoriasis.

中文翻译:

鱼油补充剂对牛皮癣的影响:一项随机对照试验的荟萃分析。

背景技术含有omega-3多不饱和脂肪酸作为有效成分的鱼油具有抗炎活性,并且在具有炎性病因的疾病中具有治疗潜力。鱼油补充剂已被提倡用于治疗牛皮癣,牛皮癣是一种慢性炎症性皮肤病。目的我们旨在研究鱼油补充剂对牛皮癣的影响。方法我们于2018年1月24日在CENTRAL,Embase和MEDLINE中搜索了补充鱼油治疗牛皮癣的随机对照试验(RCT)。使用Cochrane协作工具评估了包括在内的RCT的偏倚风险。我们进行了随机效应模型荟萃分析,以获得合并的治疗效果估计值。结果我们纳入了13项RCT,共有625名参与者。三个涉及337名参与者的RCT提供了可用于荟萃分析的数据。当通过牛皮癣面积和严重性指数评分进行评估时,鱼油补充剂并没有显着降低牛皮癣的严重程度(平均差异-0.28; 95%置信区间-1.74至1.19)。结论目前的证据不支持使用鱼油补充剂治疗牛皮癣。
更新日期:2019-12-05
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