Using an unbiased genetic screen, To et al. map genes that enhance or suppress growth defects in response to different mitochondrial inhibitors to model mitochondrial disease. The findings have novel implications for the interconnectivity of bioenergetic pathways, and suggest a provocative strategy to treat primary mitochondrial disorders.

中文翻译：

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两个线粒体错误有助于使细胞正确吗？

使用无偏遗传筛选，To等。映射增强或抑制生长缺陷的基因，以响应不同的线粒体抑制剂来模拟线粒体疾病。该发现对生物能途径的相互联系具有新颖的含义，并提出了一种治疗原发性线粒体疾病的挑衅性策略。