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Subphenotypes of NSAID-exacerbated respiratory disease identified by latent class analysis
Allergy ( IF 12.4 ) Pub Date : 2020-01-28 , DOI: 10.1111/all.14141
Natalia Celejewska-Wójcik 1 , Krzysztof Wójcik 1 , Maria Ignacak-Popiel 1 , Adam Ćmiel 2 , Katarzyna Tyrak 1 , Anna Gielicz 1 , Aleksander Kania 1 , Paweł Nastałek 1 , Marek Sanak 1 , Lucyna Mastalerz 1
Affiliation  

Induced sputum (IS) allows to measure mediators of asthmatic inflammation in bronchial secretions. NSAID‐exacerbated respiratory disease (NERD) is recognized as a distinct asthma phenotype, usually with a severe course, eosinophilic airway inflammation, and increased production of pro‐inflammatory eicosanoids. A more insightful analysis of NERD patients has shown this phenotype to be nonhomogeneous.

中文翻译:

通过潜在类别分析确定的 NSAID 加重呼吸系统疾病的亚表型

诱导痰 (IS) 允许测量支气管分泌物中哮喘性炎症的介质。NSAID 加重性呼吸系统疾病 (NERD) 被认为是一种独特的哮喘表型,通常具有严重的病程、嗜酸性气道炎症和促炎类二十烷酸的产生增加。对 NERD 患者的更深入的分析表明,这种表型是非同质的。
更新日期:2020-01-28
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