The radical-involved 1,2-difunctionalization of alkenes has developed into a robust tool for preparation of complex organic molecules. Despite significant advances in this area, the catalytic asymmetric version still remains a challenging task mainly due to the difficulty in the stereocontrol of the highly reactive radical intermediates. Recently, owing to the good single-electron transfer ability and coordination with chiral ligands of copper catalysts, remarkable achievements in radical-involved asymmetric alkene difunctionalization have been made via synergistic combination of copper and chiral ligands. This tutorial review highlights the recent progress in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes and the mechanistic scenarios governing the stereocontrol, with an emphasis on utilization of chiral ligands.

中文翻译：

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铜催化的自由基涉及烯烃的不对称1,2-双官能化的最新进展。

自由基涉及的烯烃的1,2-双官能团化已发展成为用于制备复杂有机分子的强大工具。尽管在该领域取得了重大进展，但催化不对称形式仍然是一项具有挑战性的任务，这主要是由于难以对高反应性自由基中间体进行立体控制。最近，由于良好的单电子转移能力和与铜催化剂的手性配体的配位关系，通过铜和手性配体的协同结合，在自由基参与的不对称烯烃双官能化方面取得了令人瞩目的成就。本教程的回顾重点介绍了铜催化的涉及自由基的烯烃不对称1,2-双官能化的最新进展以及控制立体控制的机理，并重点介绍了手性配体的利用。