BACKGROUND AND OBJECTIVE Retinoic acid is a metabolite of vitamin A that is necessary to maintain health in human and most of the other vertebrates. MicroRNAs (miR or miRNAs) are small, non-coding RNA particles that diminish mRNA translation of various genes and so can regulate critical cell processes including cell death, proliferation, development, etc. The aim of this review is to study interrelations between retinoic acid with miRNAs. METHODS We reviewed and summarized all published articles in PubMed, Europe PMC, and Embase databases with any relationship between retinoic acid and miRNAs from Jun 2003 to Dec 2018 that includes 126 articles. RESULTS Results showed direct and indirect relationships between retinoic acid and miRNAs in various levels including effects of retinoic acid on expression of various miRNAs and miRNA-biogenesis enzymes, and effect of miRNAs on metabolism of retinoic acid. DISCUTION AND CONCLUSION This review indicates that retinoic acid has inter-correlations with various miRNA members and their metabolism in health and disease may require implications of the other.

中文翻译：

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MicroRNA和视黄酸。

背景和目的维甲酸是维生素A的代谢产物，对于维持人类和大多数其他脊椎动物的健康是必不可少的。MicroRNA（miR或miRNA）是小的非编码RNA颗粒，可减少各种基因的mRNA翻译，因此可以调节关键的细胞过程，包括细胞死亡，增殖，发育等。与miRNA。方法我们回顾并总结了2003年6月至2018年12月在PubMed，欧洲PMC和Embase数据库中所有发表的文章以及视黄酸和miRNA之间的任何关系，其中包括126条文章。结果结果显示，视黄酸和miRNA在不同水平上都有直接和间接的关系，包括视黄酸对各种miRNA和miRNA生物发生酶表达的影响，和miRNA对视黄酸代谢的影响。讨论与结论该评论表明，视黄酸与各种miRNA成员具有相互关系，并且它们在健康和疾病中的代谢可能需要其他因素的影响。