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The Cytoskeleton as Regulator of Cell Signaling Pathways.
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2019-12-05 , DOI: 10.1016/j.tibs.2019.11.003
Ossama Moujaber 1 , Ursula Stochaj 1
Affiliation  

During interphase, filamentous actin, microtubules, and intermediate filaments regulate cell shape, motility, transport, and interactions with the environment. These activities rely on signaling events that control cytoskeleton properties. Recent studies uncovered mechanisms that go far beyond this one-directional flow of information. Thus, the three branches of the cytoskeleton impinge on signaling pathways to determine their activities. We propose that this regulatory role of the cytoskeleton provides sophisticated mechanisms to control the spatiotemporal output and the intensity of signaling events. Specific examples emphasize these emerging contributions of the cytoskeleton to cell physiology. In our opinion, further exploration of these pathways will uncover new concepts of cellular communication that originate from the cytoskeleton.

中文翻译:

细胞骨架作为细胞信号通路的调节剂。

在相间期,丝状肌动蛋白,微管和中间丝调节细胞的形状,运动性,转运以及与环境的相互作用。这些活动依赖于控制细胞骨架特性的信号传递事件。最近的研究发现了远远超出这种单向信息流的机制。因此,细胞骨架的三个分支撞击在信号传导途径上以确定它们的活性。我们建议,细胞骨架的这种调节作用提供了复杂的机制来控制时空输出和信号事件的强度。具体的例子强调了细胞骨架对细胞生理学的这些新出现的贡献。我们认为,对这些途径的进一步探索将揭示源自细胞骨架的细胞通讯新概念。
更新日期:2019-12-05
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