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Peptide-Based Vaccines: Current Progress and Future Challenges.
Chemical Reviews ( IF 62.1 ) Pub Date : 2019-12-05 , DOI: 10.1021/acs.chemrev.9b00472
Ryan J Malonis 1 , Jonathan R Lai 1 , Olivia Vergnolle 1
Affiliation  

Vaccines have had a profound impact on the management and prevention of infectious disease. In addition, the development of vaccines against chronic diseases has attracted considerable interest as an approach to prevent, rather than treat, conditions such as cancer, Alzheimer's disease, and others. Subunit vaccines consist of nongenetic components of the infectious agent or disease-related epitope. In this Review, we discuss peptide-based vaccines and their potential in three therapeutic areas: infectious disease, Alzheimer's disease, and cancer. We discuss factors that contribute to vaccine efficacy and how these parameters may potentially be modulated by design. We examine both clinically tested vaccines as well as nascent approaches and explore current challenges and potential remedies. While peptide vaccines hold substantial promise in the prevention of human disease, many obstacles remain that have hampered their clinical use; thus, continued research efforts to address these challenges are warranted.

中文翻译:

基于肽的疫苗:当前进展和未来挑战。

疫苗对传染病的管理和预防产生了深远的影响。此外,作为预防而不是治疗癌症、阿尔茨海默氏病等疾病的方法,针对慢性疾病的疫苗的开发引起了相当大的兴趣。亚单位疫苗由传染原或疾病相关表位的非遗传成分组成。在这篇综述中,我们讨论了基于肽的疫苗及其在三个治疗领域的潜力:传染病、阿尔茨海默病和癌症。我们讨论了影响疫苗功效的因素以及如何通过设计来调节这些参数。我们研究经过临床测试的疫苗和新兴方法,并探索当前的挑战和潜在的补救措施。尽管肽疫苗在预防人类疾病方面具有巨大前景,但仍然存在许多障碍阻碍其临床应用。因此,有必要继续开展研究工作来应对这些挑战。
更新日期:2019-12-05
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