Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent technological advances, new insights into the molecular mechanisms underlying glioma metabolism are rapidly emerging. In this Review, we focus on the dynamic nature of glioma metabolism and how it is shaped by the interaction between tumour genotype and brain microenvironment. Recent advances integrating metabolomics with genomics are discussed, yielding new insight into the mechanisms that drive glioma pathogenesis. Studies that shed light on interactions between the tumour microenvironment and tumour genotype are highlighted, providing important clues as to how gliomas respond to and adapt to their changing tissue and biochemical contexts. Finally, a road map for the discovery of potential new glioma drug targets is suggested, with the goal of translating these new insights about glioma metabolism into clinical benefits for patients.

中文翻译：

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改变胶质瘤中的细胞代谢——可操作的共同依赖目标的新兴景观。

改变的细胞代谢是神经胶质瘤的标志。在一系列最新技术进步的推动下，对神经胶质瘤代谢的分子机制的新见解正在迅速出现。在这篇综述中，我们关注神经胶质瘤代谢的动态特性，以及肿瘤基因型和脑微环境之间的相互作用如何塑造它。讨论了将代谢组学与基因组学相结合的最新进展，对驱动胶质瘤发病机制的机制产生了新的见解。重点介绍了阐明肿瘤微环境和肿瘤基因型之间相互作用的研究，为胶质瘤如何响应和适应其不断变化的组织和生化环境提供了重要线索。最后，提出了发现潜在新神经胶质瘤药物靶点的路线图，