We present the case of a 44-year-old physician with familial heterozygous hypercholesterolemia who experienced multiple tendon ruptures during 19 years of statin therapy and no tendon injuries in the 5 years since statins were discontinued. Statins may deleteriously affect tendon extracellular matrix by inhibiting synthesis of matrix metalloproteinases and cell cycle regulatory proteins. Clinicians should be aware of this possible association between statins and tendinopathy.

中文翻译：

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他汀类药物治疗相关的多发肌腱断裂。

我们介绍了一名44岁的家族性杂合子高胆固醇血症的医生的案例，他在他汀类药物治疗的19年中经历了多次肌腱断裂，并且自停用他汀类药物以来的5年内没有肌腱损伤。他汀类药物可能通过抑制基质金属蛋白酶和细胞周期调节蛋白的合成而有害地影响肌腱细胞外基质。临床医生应意识到他汀类药物与肌腱病之间的这种可能联系。